Tranexamic Acid in Patients Undergoing Noncardiac Surgery
TXA decreases the risk of bleeding during noncardiac surgery, but may increase the risk of cardiovascular complications.
N Engl J Med. 2022 Apr 2. doi: 10.1056/NEJMoa2201171
PMID: 35363452
Use of Labor Neuraxial Analgesia for Vaginal Delivery and Severe Maternal Morbidity
The use of neuraxial analgesia during vaginal delivery is associated with a reduction in the rate of severe maternal morbidity.
JAMA Netw Open. 2022 Feb 1;5(2):e220137
PMID: 35191971
Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial
The use of regional anesthesia for patients with hip fractures does not reduce the incidence of delirium compared to GA.
JAMA. 2022 Jan 4;327(1):50-58
PMID: 34928310
Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery
Targeting a MAP ≥75 mm Hg did not reduce postoperative complications as compared to a MAP target of ≥60 mmHg.
J Am Coll Cardiol. 2021 Nov 2;78(18):1753-1764
PMID: 34711333
Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults
Among older adults undergoing hip-fracture surgery, spinal anesthesia was not superior to general anesthesia with respect to survival and ability to walk independently at 60 days.
N Engl J Med. 2021 Nov 25;385(22):2025-2035
PMID: 34623788
Effect of Vasopressin and Methylprednisolone vs Placebo on Return of Spontaneous Circulation in Patients With In-Hospital Cardiac Arrest: A Randomized
The use of vasopressin and methylprednisolone during in-hospital cardiac arrest increases the rate of return of spontaneous circulation versus placebo, but does not increase the rate of 30 day survival or favorable neurological outcome.
JAMA. 2021 Oct 26;326(16):1586-1594
PMID: 34587236
Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic: A Randomized Clinical Trial
Healthcare workers randomized to CBD therapy experienced reduced symptoms of burnout and emotional exhaustion but had more adverse events than the standard care group.
JAMA Netw Open. 2021 Aug 2;4(8):e2120603
PMID: 34387679
Dexamethasone and Surgical-Site Infection
Dexamethasone was noninferior to placebo for the outcome of surgical site infections at 30 days.
N Engl J Med. 2021 May 6;384(18):1731-1741
PMID: 33951362